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Thinking About Cognition in Major Depressive Disorder and Other Brain-Based Illnesses 

This archived, self-directed learning activity is available for personal viewing.  The program involves a multidisciplinary faculty of clinician researchers from various facilities around the world. 


Disturbance in cognitive function is commonly observed in individuals with mood and other brain-based disorders. Available scientific literature indicates that cognitive dysfunction across psychiatric disorders is the principle mediator of psychosocial dysfunction and workplace performance. The BCDF course "Thinking about cognition in major depressive disorder and other brain-based illnesses" represents the first of a series of ongoing knowledge exchange opportunities for individuals searching for a more comprehensive and multi-dimensional knowledge of medical disorders. The course herein broadly aims to provide participants with a deeper understanding of the causes, neurobiology, assessment, and treatments of cognitive dysfunction in mood disorders. The intended audience is all mental health care professionals in primary and specialty care who are involved in the management of mood disorders.


We are confident that this course will also be of tremendous interest and value to academics, researchers, healthcare providers in training, as well as allied professionals in the public and private sector who work with individuals affected by mood disorders.


Roger S. McIntyre, Executive Director, Brain and Cognition Discovery Foundation (BCDF).

The THINC-it Tool:  

BCDF Youtube Channel: 

Course Outline 

Roger McIntyre, MD, FRCPC 

Professor of Psychiatry and Pharmacology 
Executive Director, BCDF
Head, Mood Disorders Psychopharmacology Unit 

Full Bio Here

Introduction to Course 

Duration: 3:28

Redefining Treatment Goals in Major Depressive Disorder 

Duration: 18:50

Bernhard Baune, PhD, MD, MPH,


Professor and Chair of Psychiatry
Head, Discipline of Psychiatry
University of Adelaide 

Full Bio Here

Causes of Cognitive Dysfunction in Depression 
Duration: 31:00

Catherine J. Harmer, DPhil, MA,


Professor of Cognitive Neuroscience, 
Department of Psychiatry, 
Oxford University, Oxford 

Full Bio Here

'Hot' and 'Cold' Cognitive Impairment in Depression

Duration: 26:46


John Harrison, BSc (Hons), PhD, CSci,

CPsychol, AFBPsS 

Associate Professor, Alzheimer's Centre, VUmc,

Honorary Professor, West London Mental Health

Trust, UK
Consultant Psychologist, Metis Cognition Ltd.,

Kilmington, UK

Full Bio Here

Measuring Cognition in Depression

Duration: 19:33


Larry Culpepper, MD, MPH

Professor of Family Medicine, Boston University

Full Bio Here

Depression Related Cognitive Dysfunciton in Primary Care

Duration: 20:43


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