Mark A. Frye, MD, is Chair of the Department of Psychiatry and Psychology at the Mayo Clinic and Director of the Mayo Clinic Depression Center in Rochester, Minnesota.

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Dr. Frye received his medical degree from the University of Minnesota and completed his psychiatric training at the Semel Institute for Neuroscience and Human Behavior at UCLA. He completed a subsequent research fellowship in the Biological Psychiatry Branch at the National Institute of Mental Health (NIMH) in Bethesda, Maryland, where his research focused on the neurobiology of depression and bipolar disorder. From 1998 to 2006, he served as Director of the UCLA Bipolar Disorder Research Program. 

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Dr. Frye has received numerous honors and awards both as an educator and researcher, including the 2014 Gerald Klerman Senior Investigator Award from the Depression and Bipolar Support Alliance, 2011 Mogens Schou Award for Education from the International Society for Bipolar Disorder; 2 Mayo Clinic Rome Mentorship Awards (2011, 2012); 3 UCLA departmental medical student and resident teaching awards (1994, 2003, 2005); and the 2003 Gerald Klerman Young Investigator Award from the Depression and Bipolar Support Alliance.

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Funding for Dr. Frye’s research has come from the National Institute of Mental Health, National Institute of Alcohol Abuse and Alcoholism, Stanley Medical Research Institute, American Foundation for Suicide Prevention, and industry. An active author, he has published more than 275 papers in peer-reviewed publications such as the New England Journal of Medicine, American Journal of Psychiatry, Neuropsychopharmaoclogy, Biological Psychiatry, Journal of Affective Disorder, and Journal of Clinical Psychiatry. In addition, Dr. Frye is on the Scientific Advisory Committee to the Depression and Bipolar Support Alliance and is the past Vice President of Global Outreach for the International Society of Bipolar Disorder.